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Drosophila Melanogaster As A Model For Diabetes

 663 toplam okunma

Diyabet Modeli Olarak Drosophila Melanogaster

Yazarlar: Begum COSAR1

Corresponding author
1Begum COSAR, Başkent University Faculty of Science and Letters Program of Molecular Biology and Genetics, Etimesgut, Ankara, Türkiye
E-mail: cosarbegum@gmail.com

ABSTRACT

Diabetes is a serious global concern, affecting a huge proportion of the world’s population. Recently, scientists have used D. melanogaster as a model organism for metabolic diseases such as type 2 diabetes, type 1 diabetes and obesity to study insulin signaling and metabolic pathways. The insulin pathway and glucose control of sugar metabolism human and D. melanogaster have been found to be preserved despite the physiological differences. Therefore, D. melanogaster is an optimal model for establishing a new perspective to human metabolic diseases. D. melanogaster is a more advantageous model organism compared to other invertebrate animal models due to its 75% similarity to the mammalian genome in modeling diseases seen in humans diseases. D. melanogaster diabetic disease models will help identify pathways associated with insulin resistance and the absence of additional genes related to type 2 diabetes in the future. In the near future, the high gene similarity between D. melanogaster and the mammal and the convenience of D. melanogaster in the laboratory will allow an understanding of the mechanisms underlying various metabolic diseases. In this study, recent reports which show how D. melanogaster can be one of the best model organisms for diabetes modeling using different manipulation methods have been compiled to better address the utility of the D. melanogaster type 2 diabetes model in medical research.

Keywords: Diabetes, Drosophila melanogaster, high fat diet, high sugar diet, mutation, model organism.

ÖZET

Diyabet, dünya nüfusunun büyük bir bölümünü etkileyen ciddi bir küresel sorundur. Son zamanlarda, bilim adamları D. melanogaster‘i insülin sinyalini ve metabolik yolları incelemek için tip 2 diyabet, tip 1 diyabet ve obezite gibi metabolik hastalıklar için model organizma olarak kullanmışlardır. İnsan şeker metabolizması ve D. melanogasterin insülin yolu ve glikoz kontrolünün fizyolojik farklılıklara rağmen korunduğu bulunmuştur. Bu nedenle, D. melanogaster, insan metabolik hastalıklarına yeni bir bakış açısı oluşturmak için optimal bir modeldir. D. melanogaster, insanlarda görülen hastalıkları modellemede memeli genomuna %75 benzerliği nedeniyle diğer omurgasız hayvan modellerine kıyasla daha avantajlı bir model organizmadır. D. melanogaster diyabetik hastalık modelleri, insülin direnci ile ilişkili yolları ve gelecekte tip 2 diyabet ile ilgili ek genleri belirlemeye yardımcı olacaktır. Yakın gelecekte, D. melanogaster ile memeli arasındaki yüksek gen benzerliği ve laboratuvarda D. melanogaster‘in kolay kullanımı, çeşitli metabolik hastalıkların altında yatan mekanizmaların anlaşılmasına olanak sağlayacaktır. Bu çalışmada, D. melanogaster‘in, farklı manipülasyon yöntemleri kullanarak diyabet modellemesi için en iyi model organizmalardan biri olabileceğini gösteren son raporlar, D. melanogaster tip 2 diyabet modelinin tıbbi araştırmalardaki faydasını daha iyi ele almak için derlenmiştir.

Anahtar Kelimeler: Diyabet, Drosophila melanogaster, yüksek yağ diyeti, yüksek şeker diyeti, mutasyon, model organizma.

How to Cite (APA 7)

Cosar B. (2021). Drosophila Melanogaster As A Model For Diabetes. Health Sciences Student Journal, 1(2), 46-58 https://healthssj.com/drosophila-melanogaster-as-a-model-for-diabetes/

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